The LIM Homeodomain Transcription Factor LHX6
نویسندگان
چکیده
منابع مشابه
The LIM Homeodomain Protein Lhx6 Regulates Maturation of Interneurons and Network Excitability in the Mammalian Cortex
Deletion of LIM homeodomain transcription factor-encoding Lhx6 gene in mice results in defective tangential migration of cortical interneurons and failure of differentiation of the somatostatin (Sst)- and parvalbumin (Pva)-expressing subtypes. Here, we characterize a novel hypomorphic allele of Lhx6 and demonstrate that reduced activity of this locus leads to widespread differentiation defects ...
متن کاملThe LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes.
LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies, but their identity as direct LMX1B targets remains hypothetical. We describe here the first molecular characterization of LMX1B target gene regulation. Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa ...
متن کاملLIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice.
In addition to the well known regulating effects of leptin on energy balance and glucose homeostasis through the central nervous system, circulating leptin has a direct effect on pancreatic islet and insulin secretion through its receptor (OBRb). The LIM-homeodomain transcription factor Isl-1 is expressed in all classes of pancreatic endocrine cells and is involved in regulating both islet deve...
متن کاملThe LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.
Patients with nail-patella syndrome often suffer from a nephropathy, which ultimately results in chronic renal failure. The finding that this disease is caused by mutations in the transcription factor LMX1B, which in the kidney is expressed exclusively in podocytes, offers the opportunity for a better understanding of the renal pathogenesis. In our analysis of the nephropathy in nail-patella sy...
متن کامل03-P126 New functions of the Lim-homeodomain transcription factor 2 (Lhx2) during cortical neurogenesis
ted embryo. Using the example of a Forkhead binding site, we will show that this approach allows detection of very limited changes in enhancer activity in a whole embryo and, in particular, makes possible the identification of repressor binding sites that are usually difficult to detect. We will also discuss the possible implications of the presence of this Forkhead repressor binding site on hi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.402933